Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome |
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| Authors: | Paulo C Serafini Ismael DCG Silva Gary D Smith Eduardo LA Motta André M Rocha and Edmund C Baracat |
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| Institution: | (1) Department of Gynecology, Faculdade de Medicina, Universidade de S?o Paulo, S?o Paulo, Brazil;(2) Huntington Reproductive Medicine, S?o Paulo, Brazil;(3) Department of Gynecology, Universidade Federal de S?o Paulo, S?o Paulo, Brazil;(4) Department of Obstetrics and Gynecology, Urology, Physiology, and Reproductive Science Program, University of Michigan, Ann Arbor, USA |
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| Abstract: | Background Claudin-4 (CLDN4) is one of several proteins that act as molecular mediators of embryo implantation. Recently, we examined
immunolabeling of leukemia inhibitory factor (LIF) in the endometrial tissue of 52 IVF patients, and found that LIF staining
intensity was strongly correlated with successful pregnancy initiation. In the same set of patients, we have now examined
endometrial CLDN4 expression, to see how expression intensity may vary with LIF. We examined CLDN4 in the luteal phase of
the menstrual cycle, immediately preceding IVF treatment. Our aim was to compare expression of LIF and CLDN4 in the luteal
phase, and document these patterns as putative biomarkers for pregnancy. |
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