Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus |
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Authors: | Lee Myoung-Hwa Kim Hong Lim Baek-Vin Chang Hyun-Kyung Lee Taeck-Hyun Jang Mi-Hyeon Shin Min-Chul Lee Jongseok Shin Mal-Soon Kim Chang-Ju |
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Institution: | Research Institute of Sports Science, Korea University, #1 5-ga Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea. |
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Abstract: | The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocampal neuronal activity and that endogenous opioids curtail the exercise-induced increase. |
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