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Quantitative detection of a DNA ligase reaction on a quartz-crystal microbalance. |
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| Authors: | Y Okahata Y Masunaga H Matsuno H Furusawa |
| Affiliation: | Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan. |
| Abstract: | We report here kinetic analyses of DNA ligation by using a DNA-immobilized quartz-crystal microbalance (QCM), which enables in situ real-time monitoring of both the binding of ligase and ligation reaction on DNA strands, as mass changes. |
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