| Institution: | 1. Department of Biological Sciences, University of Wisconsin‐Whitewater, , Whitewater, Wisconsin, 53190;2. Department of Health Sciences, Blackhawk Technical College, , Janesville, Wisconsin, 53545;3. Department of Chemistry, University of Wisconsin‐Whitewater, , Whitewater, Wisconsin, 53190;4. Department of Biochemistry, Medical College of Wisconsin, , Milwaukee, Wisconsin, 53226 |
| Abstract: | Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF‐16a, a putative ortholog of Caenorhabditis elegans DAF‐16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF‐16 is involved in the insulin/IGF‐I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF‐16a is a member of the FOXO family of forkhead proteins. Proteins 2014; 82:3490–3496. © 2014 Wiley Periodicals, Inc. |
