Matrix‐assisted peptide synthesis on nanoparticles |
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| Authors: | Raz Khandadash Victoria Machtey Aryeh Weiss Gerardo Byk |
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| Institution: | 1. Department of Chemistry, Laboratory of Nano‐Biomaterials, Bar Ilan University, , Ramat Gan, 52900 Israel;2. School of Engineering, Bar Ilan University, , Ramat Gan, 52900 Israel |
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| Abstract: | We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix‐assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd. |
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| Keywords: | nanoparticle peptide magnetic matrix embedded nanoparticle solid phase peptide synthesis |
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