朊病毒对中枢神经系统的影响及其作用机制

本文着重叙述了以几个问题：（１）朊病毒能否从牛转移感染到人;（２）朊病毒的感感染途径是怎样的;（３）朊病毒感染有何条件;（４）正常的朊病毒蛋白在神经元和胶质细胞表面表达有何重要功能;（５）朊病毒蛋白功能的结构基因;（６）朊病毒的可能作用机制。最后,分析了朊病毒影响中枢神经系统的两条可能途径,即破坏正常朊病毒蛋白的功能和与小神经胶质细胞共同作用提高神经元对自由基的敏感性及增加氧化自由基的含量。

Effects of prion protein on central nervous system and the mechanisms of action

The following questions are discussed in this paper: (1) Can the bovine prion protein PrpRES infect a man? (2) What is the route of PrPRES infection? (3) In what condition the PrPRES may infect animals, (4) What are the normal functions of PrPc at the surface of neurons and neuroglia cells, (5) What is the structure of the prion protein, (6) What is possible mechanism of the PrPRES destroying neurons. Finally, the two possible mechanisms of the PrPRES to affect central nervous system are analysed. One is to destroy the normal function of the PrPC, the other is to raise the sensibility of the neuron to the free radical and increase the content of the oxygen radical.