Evidence for postmeiotic expression of ribosomal RNA genes during male gametogenesis |
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| Authors: | M Schmid F J Hofgärtner Maria T Zenzes W Engel |
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| Institution: | (1) Abteilung für Humangenetik der Universität, Oberer Eselsberg, D-6900 Ulm, Federal Republic of Germany;(2) Institut für Humangenetik und Anthropologie der Universität, Albertstrasse 11, D-7800 Freiburg, Federal Republic of Germany;(3) Present address: Institut für Humangenetik der Universität, Nikolausberger Weg 5 a, Federal Republic of Germany |
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| Abstract: | Summary In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium.Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-1-phosphate uridyltransferase to the centromeric region of this chromosome (2q11-2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1. |
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