Immunomodulatory activity of hexapeptides related to proline rich peptide from colostrum |
| |
| Authors: | Kundu B Puri A Singh G Sahai R Tripathi L M Srivastava V M |
| |
| Institution: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India. |
| |
| Abstract: | Twelve analogues of an immunomodulatory hexapeptide YVPGFP (I) derived from Proline rich peptide (from colostrum) have been synthesized with modifications at positions 2, 4 and 6. In MLR assay one of the analogues exhibited approx 50% inhibition at 0.1 microg/mL concentration in contrast to prednisolone and I which caused around 70 and 20% suppression respectively, at the same concentration. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
