Identification of a variant form of tyrosine phosphatase LYP |
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| Authors: | Shaofeng Wang Hongbo Dong Jiayu Han Wanting T Ho Xueqi Fu Zhizhuang J Zhao |
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| Institution: | (1) Department of Pathology, University of Oklahoma Health Sciences Center, 73104 Oklahoma City, Oklahoma, USA;(2) Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Changchun, China;(3) School of Pharmaceutical Sciences, Jilin University, Changchun, PR China |
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| Abstract: | Background Protein tyrosine phosphatases (PTPs) are important cell signaling regulators with major pathological implications. LYP (also
known as PTPN22) is an intracellular enzyme initially found to be predominately expressed in lymphocytes. Importantly, an
allelic R620W variant of LYP is strongly associated with multiple autoimmune diseases, including systemic lupus erythematosus,
rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. |
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