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Thymidine triphosphate dephosphorylating activity in regenerating rat liver |
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| Authors: | Masaharu Kamei Shuzu Otani Iso Matsui Seiji Morisawa |
| Affiliation: | Department of Clinical Biochemistry, Christchurch Clinical School of Medicine, Christchurch Hospital, Christchurch, New Zealand |
| Abstract: | The enzyme activity of dephosphorylation of thymidine triphosphate was found in microsomal fraction of rat liver. The enzyme activity decreased at the time when [3H]thymidine incorporation into DNA of regenerating liver increased. When the [3H]thymidine incorporation was suppressed by 1,3-diaminopropane, the enzyme activity remained elevated. These results suggest that the enzyme activity appears to be closely linked to DNA synthesis. |
| Keywords: | Thymidine triphosphate Thymidine triphosphate dephosphorylation Regenerating liver Cell growth 1,3-Diaminopropane Polyamine |
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