Mitochondrial anti-viral immunity |
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| Authors: | Zemirli Naima Arnoult Damien |
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| Institution: | 1. INSERM UMR_S 1014, Hôpital Paul Brousse, Bâtiment Lavoisier, 14 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France;2. Université Paris-Sud P11, France;3. Institute of Physiology, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague, Czech Republic;6. Institute of Microbiology, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague, Czech Republic;4. Second Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague, Czech Republic;5. Departments of Physical and Macromolecular Chemistry;1. Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA;1. Dipartimento di Medicina Veterinaria e Produzioni Animali, Università di Napoli Federico II, Napoli, Italy;2. Dipartimento di Medicina Veterinaria, Università degli Studi di Bari Aldo Moro, Valenzano, Italy;3. University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Pathology Department, Cluj-Napoca, Romania;4. Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy;1. Kennedy Institute of Rheumatology, NDORMS, The University of Oxford, Headington, Oxford OX3 7FY, UK;2. Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA |
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| Abstract: | In the cytosol, the sensing of RNA viruses by the RIG-I-like receptors (RLRs) triggers a complex signaling cascade where the mitochondrial antiviral signaling protein (MAVS) plays a crucial role in orchestrating the innate host response through the induction of antiviral and inflammatory responses. Hence, in addition to their known roles in the metabolic processes and the control of programmed cell death, mitochondria are now emerging as a fundamental hub for innate anti-viral immunity. This review summarizes the findings related to the MAVS adapter and mitochondria in the innate immune response to RNA viruses. |
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