XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions |
| |
| Authors: | Oliver Mortusewicz Heinrich Leonhardt |
| |
| Affiliation: | (1) Department of Biology II, Ludwig Maximilians University Munich, 82152 Planegg-Martinsried, Germany |
| |
| Abstract: | Background Genome integrity is constantly challenged and requires the coordinated recruitment of multiple enzyme activities to ensure efficient repair of DNA lesions. We investigated the dynamics of XRCC1 and PCNA that act as molecular loading platforms and play a central role in this coordination. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
