Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus |
| |
Authors: | Kathryn E Evans Simon W Fox |
| |
Institution: | (1) Ecotoxicology and Stress Biology Research Group, School of Biological Science, University of Plymouth, Plymouth, UK |
| |
Abstract: | Background IL-10 has a potent inhibitory effect on osteoclastogenesis. In vitro and in vivo studies confirm the importance of this cytokine
in bone metabolism, for instance IL-10-deficient mice develop the hallmarks of osteoporosis. Although it is known that IL-10
directly inhibits osteoclastogenesis at an early stage, preventing differentiation of osteoclast progenitors to preosteoclasts,
the precise mechanism of its action is not yet clear. Several major pathways regulate osteoclastogenesis, with key signalling
genes such as p38, TRAF6, NF-κB and NFATc1 well established as playing vital roles. We have looked at gene expression in eleven
of these genes using real-time quantitative PCR on RNA extracted from RANKL-treated RAW264.7 monocytes. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|