Aggravation by halomethanes of damages in isolated erythrocyte membranes photosensitized by porphyrins |
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| Authors: | Tsvirko M P Vorobeĭ A V Gurinovich V V |
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| Institution: | Institute of Photobiology, National Academy of Sciences of Belarus, ul. Akademicheskaya 27, Minsk, 220072 Belarus. |
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| Abstract: | It was found that halogen methanes (CCl4, CHBr3) enhance the destruction of protein tryptophanyls and lipid peroxidation photosensitized by Zn-tetraphenylporphin and Zn-tetramethylpyridylporphyrin in isolated erythrocyte membranes. It was shown that this effect is due to photoinduced electron transport from Zn-porphyrins to halogen methanes with the formation of highly reactive halogenmethyl radicals. The hydrophilic Zn-tetramethylpyridylporphyrin is more active at the photosensition of damage to membrane proteins, whereas the hydrophobic Zn-tetraphenylporphin is more effective in lipid peroxidation. |
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