| 蝮蛇毒诱导小鼠急性肾损伤的研究 |
| |
| 引用本文： | 张友其,邓立普,彭韦霞,刘灿芬.蝮蛇毒诱导小鼠急性肾损伤的研究[J].蛇志,2011,23(1):11-14,46. |
| |
| 作者姓名： | 张友其 邓立普 彭韦霞 刘灿芬 |
| |
| 作者单位： | 1. 湖南益阳市中心医院ICU,湖南益阳,413000
2. 南华大学附属南华医院急诊科,湖南衡阳,421002 |
| |
| 摘 要： | 目的观察蝮蛇毒诱导小鼠急性肾损伤肾脏病理变化特点,为肾损伤的防治提供理论依据。方法将小鼠分为N组（正常对照组）、L组（蛇毒低剂量组,0.50 mg/kg）、H组（蛇毒高剂量组,2.00 mg/kg）,每组按时相点又分为3、6、244、8 h四个亚组。96只小鼠随机分配到各亚组,采取肌注蝮蛇毒的方式建立动物模型。结果 SCr值,L组24 h升高（P〈0.05）,48 h下降（P〈0.05）;H组持续升高（P〈0.05）。光镜下肾损伤病理评分,L组6 h开始升高（P〈0.05）,48 h下降（P〈0.05）;H组3 h开始持续升高（P〈0.05）。SCr与光镜下,肾损伤病理评分呈正相关（L组：r=0.883,P〈0.01;H组：r=0.891,P〈0.01）。结论 SCr在一定条件下能反映肾损伤的严重程度,但急性肾损伤的发生早于SCr升高;急性肾损伤的严重程度与蝮蛇毒的剂量呈正相关。
|
| 关 键 词： | 急性肾损伤 蝮蛇毒 小鼠 |
Actue kidney injury of mice induced by Agkistrodon halys pallas venom |
| |
| ZHANG You-qi,DENG Li-pu,PENG Wei-xia,LIU Can-fen.Actue kidney injury of mice induced by Agkistrodon halys pallas venom[J].Journal of Snake,2011,23(1):11-14,46. |
| |
| Authors: | ZHANG You-qi DENG Li-pu PENG Wei-xia LIU Can-fen |
| |
| Institution: | ZHANG You-qi1,DENG Li-pu2,PENG Wei-xia1,LIU Can-fen1(1.ICU of the Central Hospital of Yiyang,Yiyang,Hunan,413000,China,2.Emergency Department of Nanhua Hospital Affiliated to University of South,Hengyang,421002,China) |
| |
| Abstract: | Objective To observe the changes of pathology in kidney and to provide a theoretical basis for prevention and treatment of renal injury induced by Agkistrodon halys Pallas venom.Methods Three groups were designed in this experiment:group N(normal control group),group L(low-dose group,0.50 mg/kg) and group H(high-dose group,2.00 mg/kg) according to the dose of Agkistrodon halys Pallas venom.All were further divided into four sub groups at 3 h,6 h,24 h and 48 h.A total of 96 Kunming mice were randomly equally... |
| |
| Keywords: | Actue renal injury Agkistrodon halys Pallas venom Mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
