alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells. |
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| Authors: | Y Nobata M Urakaze R Temaru A Sato N Nakamura K Yamazaki M Kishida M Takata M Kobayashi |
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| Institution: | Toyama Medical and Pharmaceutical University, Faculty of Medicine, First Department of Internal Medicine, 2630 Sugitani, Toyama-shi, Japan. |
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| Abstract: | It has been reported that alpha-tocopherol, an antioxidant agent, may play a role in preventing diabetic angiopathy. However, there is little evidence to show the effect of alpha-tocopherol on the production of pro-inflammatory cytokines in endothelial cells. Therefore, we examined the effect of alpha-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells. Thrombin alone markedly increased the IL-8 release. Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and alpha-tocopherol diminished their effect; alpha-tocopherol also inhibited the phosphorylation of IkappaB-alpha induced by high glucose levels and/or thrombin. Our results suggest that the administration of alpha-tocopherol to diabetic patients may have a beneficial effect for the prevention of diabetic vascular complications by the inhibition of IL-8 synthesis from endothelial cells. |
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