Interaction of a synthetic peptide of the interferon alpha-2 C-terminal part with human blood leukocytes. Binding to peripheral blood mononuclear cells. |
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| Authors: | A V Danilkovitch A I Kharitonenkov K V Freze A F Shevalier O V Kolosova T V Bulargina A F Kirkin M V Gusev |
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| Institution: | Moscow State University, Biological Faculty, USSR. |
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| Abstract: | A biologically active synthetic peptide, 2438, representing the 124-138 amino acid sequence of the human interferon alpha-2 (IFN alpha-2) molecule, which is known to possess IFN-like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different Kd values, for the 'low' and 'high' affinity binding. The interaction of the 125I-labelled peptide 2438 with the cells is not impaired by human IFN alpha-2 or cholera toxin. |
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