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Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations |
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| Authors: | Ekaterine Kortkhonjia Relly Brandman Joe Zhongxiang Zhou Vincent A Voelz Ilya Chorny Bruce Kabakoff Thomas W Patapoff Ken A Dill Trevor E Swartz |
| Institution: | 1.Early Stage Pharmaceutical Development Department; Genentech Inc.; San Francisco, CA USA;2.Simprota Corporation; San Francisco, CA USA;3.Department of Chemistry; Stanford University; Stanford, CA USA;4.Laufer Center for Physical and Quantitative Biology; Stony Brook University; Stony Brook, NY USA |
| Abstract: | |
| Keywords: | fluorescence anisotropy molecular dynamics simulations monoclonal antibodies solution dynamics therapeutic antibodies |