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Copper(II) pyridinecarboxylate adducts with chelating ligands as potential antimicrobial agents |
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| Authors: | Peter Segla Dušan Mikloš Barbora Kaliňáková Martina Palicová Marian Valko Tadeusz Glowiak |
| Institution: | a Department of Inorganic Chemistry, Slovak Technical University, Radlinskeho 9, SK81237 Bratislava, Slovakia b Department of Biochemistry and Microbiology, Slovak Technical University, 81237 Bratislava, Slovakia c Department of Physical Chemistry, Slovak Technical University, 81237 Bratislava, Slovakia d Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50383 Wroclaw, Poland |
| Abstract: | The synthesis and characterization of seven new solid complexes, Cu(2-MeSnic)2 (phen)] (2-MeSnic = 2-methylthionicotinate, phen = 1,10-phenanthroline), CuX2(bipy)(H2O)] (X = 2-MeSnic or nic (nicotinate), bipy = 2,2′-bipyridine), Cu(isonic)2(bipy)(H2O)] · H2O (isonic = isonicotinate), Cu(bipy)2(H2O)](2-MeSnic)2 · 3H2O, Cu(phen)2(H2O)](isonic) 2 · 2H2O and Cu(phen)2(H2O)](nic)2 · 3H2O, are reported. The composition and stereochemistry as well as the mode of ligand coordination have been determined by elemental analysis, IR, electronic and EPR spectra. The carboxyl group of the pyridinecarboxylate anions coordinates to the Cu(II) atom as an unidentate or as a chelating ligand. The EPR spectra of studied complexes are monomeric except for the spectrum of Cu(2-MeSnic)2(bipy)(H2O)], which shows triplet state feature. Half-field transition, observed for Cu(2-MeSnic)2(bipy)(H2O)], Cu(bipy)2(H2O)](2-MeSnic)2 · 3H2O and Cu(phen)2(H2O)](nic)2 · 3H2O, was used to estimate the interspin copper-copper distances. In all cases, the available evidence supports square-pyramidal environment about the copper(II) atom, which is confirmed by crystal and molecular structure of one of the products, namely Cu(2-MeSnic)2(bipy)(H2O)]. The antimicrobial effects have been tested on various strains of bacteria, yeasts and filamentous fungi. |
| Keywords: | Crystal structure Chelating ligands Antimicrobial agent Pyridinecarboxylate complexes Copper(II) complexes Monomeric complexes Half-field transition |
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