A novel ruthenium nitrosyl complex which also contains a free NO-donor moiety |
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| Authors: | Darren Griffith Enzo Alessio |
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| Institution: | a Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland
b Dipartimento di Scienze Chimiche, Università di Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy |
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| Abstract: | The synthesis and characterisation of a novel ruthenium nitrosyl complex with coordinated 4-pyridinehydroxamic acid, NBu4]cis-RuCl4(4-pyha)NO] (4-pyha=4-pyridinehydroxamic acid, NO=nitric oxide) is reported. NBu4]cis-RuCl4(4-pyha)NO] was prepared from the precursor, NBu4trans-RuCl4(dmso-O)NO] (dmso=dimethylsulfoxide) upon treatment with 4-pyridinehydroxamic acid. NBu4]cis-RuCl4(4-pyha)NO] possesses the linear {RuII(NO)+} moiety and a cis-pyridinehydroxamic acid group which has the potential to act as an NO donor. The crystal structure of NBu4]cis-RuCl4(4-pyha)NO] was also determined. The nitrosyl complex is novel in that, besides coordinated NO, it also contains a ligand which has the potential to release NO. |
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| Keywords: | Nitric oxide Hydroxamic acids Ruthenium Ruthenium nitrosyl complexes Nitric oxide donors |
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