Cytochrome P450 aromatase expression in human seminoma |
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| Authors: | Vittoria?Rago Francesco?Romeo Saveria?Aquila Daniela?Montanaro Sebastiano?Andò Email author" target="_blank">Amalia?CarpinoEmail author |
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| Institution: | (1) Cell Biology Department, Faculty of Pharmacy, University of Calabria, Calabria, Italy;(2) Pathologic Anatomy Unit, Annunziata Hospital, Cosenza, Italy;(3) Pharmaco-Biology Departments, Faculty of Pharmacy, University of Calabria, Calabria, Italy |
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| Abstract: | Background The enzyme cytochrome P450 aromatase, catalysing the conversion of androgens into estrogens, has been detected in normal human
testicular cells suggesting a physiological role of local estrogen biosynthesis on spermatogenesis control. Estrogens, regulating
cell growth and apoptosis, can also be involved in tumorigenesis process, but the possible link between estrogens and testicular
neoplastic process is, up to now, scarcely known. This study examined aromatase expression in human seminoma, which is the
most common germ cell tumour of the testis. |
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