| Affiliation: | (1) Cell Biology Department, Faculty of Pharmacy, University of Calabria, Calabria, Italy;(2) Pathologic Anatomy Unit, Annunziata Hospital, Cosenza, Italy;(3) Pharmaco-Biology Departments, Faculty of Pharmacy, University of Calabria, Calabria, Italy |
| Abstract: | Background The enzyme cytochrome P450 aromatase, catalysing the conversion of androgens into estrogens, has been detected in normal human testicular cells suggesting a physiological role of local estrogen biosynthesis on spermatogenesis control. Estrogens, regulating cell growth and apoptosis, can also be involved in tumorigenesis process, but the possible link between estrogens and testicular neoplastic process is, up to now, scarcely known. This study examined aromatase expression in human seminoma, which is the most common germ cell tumour of the testis. |
