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Comparison of normalization methods for CodeLink Bioarray data |
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| Authors: | |
| Institution: | (1) Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA;(2) Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA;(3) Center for Automated Learning and Discovery and Language Technology Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA |
| Abstract: | BackgroundThe quality of microarray data can seriously affect the accuracy of downstream analyses. In order to reduce variability and enhance signal reproducibility in these data, many normalization methods have been proposed and evaluated, most of which are for data obtained from cDNA microarrays and Affymetrix GeneChips. CodeLink Bioarrays are a newly emerged, single-color oligonucleotide microarray platform. To date, there are no reported studies that evaluate normalization methods for CodeLink Bioarrays. |
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