Radiation-inducible gene therapy |
| |
Authors: | Mauceri H J Hanna N N Staba M J Beckett M A Kufe D W Weichselbaum R R |
| |
Institution: | Department of Radiation and Cellular Oncology, University of Chicago, IL 60637, USA. rrw@rover.uchicago.edu |
| |
Abstract: | The radiation-inducible chimeric genetic construct Egr-TNF alpha introduced into human xenografts produces cytotoxicity of infected tumor cells resulting in tumor growth inhibition. The interaction between Egr-TNF and radiation is selectively cytotoxic for the tumor microvasculature resulting in vascular thrombosis and tumor necrosis. Gene therapy combined with radiation therapy offers great potential for the treatment of localized human cancers. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |