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| GnRH受体与TRAIL在前列腺肿瘤中表达的研究 | |
| 引用本文： | 殷玉华,姬秋和,黄威权,刘雪松,付建芳,高彬,金伯泉.GnRH受体与TRAIL在前列腺肿瘤中表达的研究[J].中国组织化学与细胞化学杂志,2004,13(2):236-239. |
| 作者姓名： | 殷玉华 姬秋和 黄威权 刘雪松 付建芳 高彬 金伯泉 |
| 作者单位： | 1. 第四军医大学西京医院内分泌科 2. 第四军医大学组织胚胎教研室 3. 第四军医大学免疫教研室,西安,710032 |
| 摘 要： | 目的研究促性腺激素释放激素受体(GnRH-R)和凋亡相关蛋白(TRAIL)在前列腺肿瘤中的表达及临床意义.方法采用SABC免疫组化法及原位定量法,对前列腺肿瘤和前列腺增生患者中GnRH-R和TRAIL的表达进行检测及半定量分析.结果在前列腺癌组织高分化的11例,中分化的4例以及低分化的5例中,各种不同分化的癌组织均显示不同程度的GnRH-R和TRAIL阳性免疫反应,原位定量显示GnRH-R与TRAIL的表达均分别随着组织分化程度增高而增高(P<0.05),并且TRAIL较GnRH-R阳性免疫反应强.结论 GnRH-R和TRAIL表达量可能与前列腺恶性肿瘤的发生与发展有关. |
| 关 键 词： | 促性腺激素释放激素受体 凋亡素2配体 前列腺肿瘤 免疫组织化学 |
| 修稿时间： | 2004年1月7日 |
STUDIES ON EXPRESSION OF GONADOTROPIN RELEASING HORMONE RECEPTOR AND TRAIL IN PROSTATE TUMOR |
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| Yin Yuhua,Ji Qiuhe,Huang Weiquan,Liu Xuesong,Fu Jianfang,Gao Bing,Jin Boquan.STUDIES ON EXPRESSION OF GONADOTROPIN RELEASING HORMONE RECEPTOR AND TRAIL IN PROSTATE TUMOR[J].Chinese Journal of Histochemistry and Cytochemistry,2004,13(2):236-239. | |
| Authors: | Yin Yuhua Ji Qiuhe Huang Weiquan Liu Xuesong Fu Jianfang Gao Bing Jin Boquan |
| Abstract: | ? Objective To investigate the expression of gonadotropin-releasing hormone receptor (GnRH-R) and apoptosis related protein TRAIL in prostate tumor and to discuss its clinical significance. Method The expressions of TRAIL and GnRH-R in 20 cases of prostate carcinoma and 6 prostate benign hyperplasia were observed with immunohistochemical method SABC and in situ quantification. Result The TRAIL and GnRH-R positive immunoreactive substances were located in the tumor cells of prostate tumors. In the 20prostate tumor patients, the expression ofTRAIL andGnRH-R increased in accordance with their degree of histologic differentiation (P<0.05).Conclusion GnRH-R and TRAIL may be related to the pathogenesis and development of the prostate tumor and thus maybe used as a discriminator of prostate tumors. |
| Keywords: | Gonadotropin-releasing hormone receptor TRAIL Prostate tumor Immunohistochemistry |
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