Synthesis of 1-(3-Azido-2,3-Dideoxy-Beta-D-Ribo-Hexofuranosyl)Thymine |
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| Authors: | Merrick R Almond Gregory T Lowen Gary E Martin Janet L Rideout |
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| Institution: | Burroughs Wellcome Co. , 3030 Cornwallis Rd., Research Triangle Park, N. C., 27709, U.S.A. |
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| Abstract: | Abstract The nucleoside derivative 1-(3-azido-2,3-dideoxy-beta-D-ribo-hexofuranosyl)thymine has been synthesized from 3-0-benzyl-1,2-0-isopropylidene-alpha-D-glucofuranose-5,6-carbonate in an overall yield of 16%. The key step in the synthesis involves the selective deacetylation of a nucleoside derivative having a cyclic carbonate moiety. |
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