APEC,An A2-Selective Adenosine Agonist,is a More Potent Locomotor Depressant Than N6-Cyclohexyladenosine |
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| Authors: | Kenneth A. Jacobson Olga Nikodijevic David de la Cruz John W. Daly |
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| Affiliation: | Laboratory of Bioorganic Chemistry , National Inst. of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health , 20892, Bethesda, MD |
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| Abstract: | Abstract The locomotor depressant effects of APEC are due to activation of central A2 adenosine receptors, while the depressant effects of NECA are dependent primarily on A1-receptor activation. A variety of potent A1-antagonists, including conjugates of the XAC, were screened as antagonists; 2-thio-CPX and CPT reversed effects of CHA, but not of APEC. |
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