Glycosylation of 2-Thiouracil Derivatives. A Synthetic Approach to 3-Glycosyl-2, 4-dioxypyrimidines |
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| Authors: | A. I. Khodair E. E. Ibrahim E. S. H. El Ashry |
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| Affiliation: | 1. Department of Chemistry, Faculty of Education , Tanta University , Kafer EL-Sheikh Branch, Tanta, Egypt;2. Department of Chemistry, Faculty of Science , Suez Canal University , Ismailia, Egypt;3. Department of Chemistry, Faculty of Science , Alexandria University , Alexandria, Egypt |
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| Abstract: | Abstract Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a-h. However, their deacetylation with ammonia in methanol caused a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h. |
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