Synthetic and Antiviral Studies on Certain Acyclic Nucleosides of 5-Benzyl-6-Azauracil Derivatives |
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| Authors: | Yeh-Long Chen Shwu-Jing Chen Kuan-Han Lee Bor-Ruey Huang Cherng-Chyi Tzeng |
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| Institution: | School of Chemistry Kaohsiung Medical College , Kaohsiung City, 807, Taiwan, Republic of China |
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| Abstract: | Abstract Several 5-(4-substituted benzyl)-6-azauracils have been synthesized from the corresponding benzaldehydes. The 5-benzyl-6-azauracils were silylated with hexamethyldisilazane and then glycosylated with aliphatic halides, e.g., (2-acetoxyethoxy)methyl bromide and 1,3-dibenzyloxy-2-chloromethoxypropane, to give protected acyclic nucleosides which were deprotected to afford acyclonucleosides of 5-(4-substituted benzyl)-6-azauracils. None of the compounds exhibited significant antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. |
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