Antiviral Nucleoside Analogues with Axial Chirality |
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| Authors: | Jiri Zemlicka |
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| Affiliation: | Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine , Detroit, Michigan, 48201-1379 |
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| Abstract: | Abstract Chemistry and biological activity of nucleoside analogues comprising a chiral axis will be reviewed with emphasis on anti-HIV agent adenallene (1a) and anti-HIV/HBV analogue cytallene (1b). Possible mechanism of action, activity toward the enzymes of nucleic acid metabolism and structure-activity relationships will be discussed. |
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