Synthesis and Biological Properties of (+) and (-)-(E)-5-(2-bronovinyl)-21 -deoxy-11 a-Carbauridine |
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| Authors: | Jan Balzarini Harald Baumgartner Michael Bodenteich Erik De Clercq Herfried Griengl |
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| Institution: | 1. Rega Institute for Medical Research, Katholieke Universiteit Leuven , Minderbroederstraat 10, B-3000, Leuven, Belgium;2. Institute of Organic Chemistry, Graz University of Technology , Strenayrgasse 16, A-8010, Gras, Austria |
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| Abstract: | Abstract Carbocyclic (+)- and (-)-(E)-5- (2-bromovinyl)-2′-deoxyuridlne have been prepared from (+)- and (-)-endo-norborn-5-en-2-y1 butyrate. In cell cultures both (+)- and (-)-C-BVDU showed activity against herpes simplex virus types 1 and 2, (+)-C-BVDU being only slightly less active than BVDU itself. (-)-C-BVDU gave a smaller but still significant antiviral effect. A nomenclature for carbocyclic nucleosides is proposed. |
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