Synthesis,Biophysical Properties,and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages |
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| Authors: | Radhakrishnan P Iyer Dong Yu Theresa Devlin Nan-Hui Ho Suzanne Johnson Sudhir Agrawal |
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| Institution: | Hybridon Inc. , One Innovation Drive, Worcester, MA, 01605 |
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| Abstract: | Abstract Mixed backbone oligonucleotides (MBOs) (containing ionic and non-ionic internucleotidic linkages) in which the non-ionic segments are either methylphosphotriester (PO-OMe) or primary phosphoramidate (PO-NH2) linkages have been prepared using the recently described N-pent-4-enoyl (PNT) nucleoside phosphoramidates and H-phosphonates. Biophysical properties and stability studies suggest that these MBOs are novel antisense molecules. |
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