Carboxyamidation of Purine Nucleosides: New Secondary 8-Carboxamidopurine Nucleosides |
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Authors: | Chi Tu Charlene Keane Bruce Eaton |
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Institution: | Medicinal Chemistry Department , NeXstar Pharmaceuticals Inc. , 2860 Wilderness Place, Boulder , CO , 80301 |
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Abstract: | Abstract Palladium catalyzed carboxyamidation at the 8-position of 8-bromoadenosine and 8-bromoguanosine nucleosides is a versatile reaction, which allows primary, secondary, heterocyclic, aromatic mine and amino acids to be incorporated into purine nucleosides. |
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Keywords: | D/L-arabinonucleosides D/L-ribonucleosides natural phosphate catalyst one-pot synthesis |
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