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Nucleoside H-Phosphonates. IX. Possible Side-Reactions During Hydrogen Phosphonate Diester Formation |
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| Authors: | Tor Regberg Jacek Stawinski Roger Ströberg |
| Institution: | Department of Organic Chemistry , Arrhenius Laboratory, University of Stockholm , 106 91, Stockholm, Sweden |
| Abstract: | Abstract Possible side-reactions during hydrogenphosphonate diester formation in the presence of various condensing reagents (e.g. arensulfonyl derivatives, chlorophosphates and acyl chlorides) have been investigated using 31P NMR spectroscopy. |
| Keywords: | 3′-Azido-3′-deoxythymidine 5′-[32P]-choline phosphate [32P]orthophos-phoric acid Phosphorylation Synthesis of [32P]-labeled nucleotides |