A Potent,Selective, Non-Substrate Inhibitor of HSV-I Thymidine Kinase: (±)-9-[[(Z)-2-(Hydroxymethyl)Cyclohexyl]Methyl]Guanine and Related Compounds |
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| Authors: | W T Ashton L C Meurer R L Tolman J D Karkas R Liou H C Perryt |
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| Institution: | 1. Merck Sharp &2. Dohme Research Laboratories , Rahway, NJ, 07065;3. West Point, PA 19486, New York, NY, 10016 |
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| Abstract: | Abstract The title compound was prepared and found to be a potent and selective inhibitor of HSV-I thymidine kinase. This compound delayed the reactivation of latent virus from explanted mouse ganglia but exacerbated the primary HSV-I infection in mice. |
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