Phosphate Modified Analogues of 5′-O-Phosphorylated 2′,3′-Dideoxynucleosides: Synthesis and Anti-HIV Activity |
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| Authors: | Robert M Rigs Robert N Comber John A Montgomery John A Secrist III Janet M Leeds Sara Chaffee |
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| Institution: | 1. Southern Research Institute, Organic Chemistry Research Department , Birmingham, Alabama, 35255;2. Medical Center, Duke University , Durham, North Carolina, 27710 |
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| Abstract: | Abstract Phosphonate analogues of 5′-O-phosphoryl-2′,3′-dideoxyribofuranosyl adenine, cytosine, hypoxanthine and thymine were synthesized. The hypoxanthine and thymine analogues were inactive against HIV induced cyopathy in the CEM-4 T-cell lines. The 2′,3′-ddC and 2′,3′-ddA analogues were marginally active. |
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