Phosphotriester Synthesis of Oligonucleotides with the Use of N- and O-Nucleophilic Intramolecular Catalysis |
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| Authors: | V. A. Efimov A. A. Buryakova N. N. Polushin I. Y. Dubey O. G. Chakhmakhcheva Yu. A. Ovchinnikov |
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| Affiliation: | Shemyakin Institute of Bioorganic Chemistry USSR Academy of Sciences , ul. Miklukho- Maklaya 16/10, Moscow, 117871, USSR |
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| Abstract: | Abstract An effective method for the synthesis of oligonucleotides by the phosphotriester approach has been developed. It is based on the use of phosphate protecting groups enabling O-nucleophilic intramolecular catalysis. |
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