Phosphotriester Synthesis of Oligonucleotides with the Use of N- and O-Nucleophilic Intramolecular Catalysis |
| |
| Authors: | V A Efimov A A Buryakova N N Polushin I Y Dubey O G Chakhmakhcheva Yu A Ovchinnikov |
| |
| Institution: | Shemyakin Institute of Bioorganic Chemistry USSR Academy of Sciences , ul. Miklukho- Maklaya 16/10, Moscow, 117871, USSR |
| |
| Abstract: | Abstract An effective method for the synthesis of oligonucleotides by the phosphotriester approach has been developed. It is based on the use of phosphate protecting groups enabling O-nucleophilic intramolecular catalysis. |
| |
| Keywords: | |
|
|
