Nucleosides,III1 Synthesis and Properties of 2-Trifluoromethyl-Naphthimidazole-Ribonucleoside |
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| Authors: | Abdullah Hijazi |
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| Affiliation: | Dept. of Chemistry , King Saud University , Riyadh, Saudi Arabia |
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| Abstract: | Abstract The fusion reaction between 2-trifluoromethylnaphth[2,3-d]imidazole (1) and 1-0-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (2) leads to 2,3′,5′-tri-O-benzoyl-1-β-D-ribofuranosylnaphth[2,3-d]imidazole (3). Debenzoylation of (3) gives the corresponding nucleoside 1-β-D-ribofuranosyl -2-trifluoromethylnaphth[2,3-d]imidazole (4). Structural proofs are based on elementary analysis, UV-and 1H-NMR spectra. |
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