Synthesis,Biochemical and Chemotherapeutic Activity of Some Azolo[1,3]Oxazine Nucleosides |
| |
| Authors: | Leroy B Townsend Vladimir G Beylin Linda L Wotring |
| |
| Institution: | 1. Department of Medicinal Chemistry , College of Pharmacy Ann Arbor, MI , 48109–1065, U.S.A.;2. Department of Chemistry , The University of Michigan Ann Arbor, MI , 48109–1065, U.S.A.;3. Department of Medicinal Chemistry , College of Pharmacy Ann Arbor, MI , 48109–1065, U.S.A. |
| |
| Abstract: | Abstract The synthesis of several 3,5,7-trisubstituted pyrazolo-3,4-e]1,3]oxazines by ring annulation of the appropriately substituted pyrazoles is described. These specific compounds can be viewed as analogs of the C-nucleoside antibiotics formycin, formycin B and oxoformycin B. The biochemical and chemotherapeutic activity of these pyrazolo3,4-e]1,3]oxazines is also disscussed. |
| |
| Keywords: | |
|
|
