Synthesis and Antiviral Evaluation of Adenosine-N1-Oxide and 1-(Benzyloxy) Adenosines |
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| Authors: | Charles A Krauth Anita T Shortnacy John K Montgomery John A Secrist III |
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| Institution: | Organic Chemistry Research Department , Southern Research Institute , P. O. Box 55305, Birmingham, AL, 35255-5305 |
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| Abstract: | Abstract The antiviral activity of adenosine-N1-oxide (1) and a variety of substituted 1-(benzyloxy) adenosines (2) has been re-investigated and significant in vitro activity vs. Vaccinia virus has been shown. In vivo activity in mice has also been demonstrated. |
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