Isolation and Characterization of a Novel Nucleoside from the Urines of Chronic Myelogenous Leukemia Patients |
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| Authors: | Girish B Chhed Helen B Patrzyc Arvind K Bhargava Pamela F Crain Satinder K Sethi James A McCloskey |
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| Institution: | 1. Departments of Biophysics and Roswell Park Memorial Institute , Buffalo, New York, 14263;2. Laboratory Medicine and Roswell Park Memorial Institute , Buffalo, New York, 14263;3. Departments of Medicinal Chemistry and Biochemistry , University of Utah , Salt Lake City, Utah, 84112;4. Biochemistry, University of Utah , Salt Lake City, Utah, 84112 |
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| Abstract: | Abstract From 24 hour collections of urines of chronic myelogenous leukemia (CML) patients, a novel nucleoside was isolated. It was assigned the structure, 5′-deoxyinosine (I) on the basis of UV, NMR and mass spectrometry and by comparison of the spectral data and HPLC and TLC mobilities with those of the authentic sample. Another nucleoside, 5′-deoxy-5′-methylthioadenosine sulfoxide previously isolated from the urines of immunodeficient children was also found in the urine of a CML patient. Possible origin and significance of both of these nucleosides are discussed. |
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