2-Deoxy-D-Ribofuranosylation of Ethyl 5-Aminoimidazole-4-Carboxylate by Biotransformation and Chemical Methods |
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| Authors: | David Ewing Robert W Humble Antonin Holy Grahame Mackenzie Gordon Shaw Ivan Votruba |
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| Institution: | 1. University of Hull , Hull, HU6 7RX, U.K.;2. Humberside College of Higher Education , Hull, HU6 7RT, U.K.;3. University of Bradford , Bradford, BD7 1DP, U.K.;4. Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences , 16610, Praha 6, Czechoslovakia |
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| Abstract: | Abstract In our studies aimed at the synthesis of inhibitors of enzymes involved in the de novo biosynthesis of purine nucleotides, the arabinosyl nucleoside (la), which is analogous to CAIR (lb), a central intermediate in the pathway, showed significant inhibition and substrate activities. We were therefore interested to synthesize the related 2-deoxy-D-ribosyl nucleotide (lc) for further enzymological studies. |
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