DNA Duplexes Containing Alpha Anomeric Nucleotides and Polarity Reversals: Coexistence of Parallel and Antiparallel DNA |
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| Authors: | Markus W. Gerrnann James M. Aramini Bernd W. Kalisch Richard T. Pon Johan H. van de Sande |
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| Affiliation: | 1. Department of Pharmacology , Kimmel Cancer Institute, Thomas Jefferson University , Philadelphia, PA, 19107;2. Department of Medical Biochemistry , University of Calgary , Calgary, Alberta, Canada , T2N 4N1 |
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| Abstract: | Abstract Oligodeoxynucleotides that possess alpha anomeric nucleotides and polarity reversals show promise for application in the area of antisense therapy. Here we provide a survey of the spectroscopic, thermodynamic, and enzymatic techniques used in our laboratories to investigate model systems containing such unnatural features with the ultimate goal of designing a new class of more potent and effective antisense therapeutics. |
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