The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of Dinucleostde Trifluoromethylphosphonates |
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| Authors: | Rosa Maria Karl Wolfgang Richter Roland Kl?sel Michael Mayer Ivar Ugi |
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| Institution: | 1. Institut für Physiologische Chemie, Technische Universitat München , Biedersteinerstra?e 29, D-80802 , München , Germany;2. Institut für Organische Chemie und Biochemie, Technische Universit?t München , Lichtenbergstra?e 4, D-85747 , Garching , Germany |
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| Abstract: | Abstract The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5′-O-DATE-thymidine and 3′-O-acetyl-thymidine are phosphorylated with CF3P(NR2)2 to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate. |
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