Novel DNA Damage Mediated by Oxidation of Various Modified Nucleotide Residues |
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| Authors: | Hideo Inoue Shiro Koizume Takahiro Yamauchi Kouichi Murata Eiko Ohtsuka |
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| Institution: | Faculty of Pharmaceutical Sciences , Hokkuido University , Kita-12, Nishi-6, Kita-ku, Sapporo, 060, Japan |
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| Abstract: | Abstract Permanganate reaction of DNA oligomers containing an 8-oxoadenine or 5hydroxyuracil residue was studied, and the results were compared with those for an 8-oxoguanine-containing oligomers. We obtained similar results and found that the nucleotide residues neighboring the modified base were damaged and that the novel damage was induced by the oxidation of the modified base. |
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