Acyclic Nucleosides other than Acyclovir as Potential Antiviral Agents |
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Authors: | Richard J Remy John A Secrist III |
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Institution: | Southern Research Institute Birmingham , Alabama, 35255-5305 |
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Abstract: | Abstract In the past few years interest in the synthesis and biological properties of acyclic nucleosides has been generated based largely upon the development of acyclovir 9-(2-hydroxyethoxy)methyll guanine, 1a] as an antiviral agent for the treatment of certain herpesvirus infections. The literature in the area covers a variety of different heterocycles, a variety of different side chains, and spans research that is strictly synthetic to research that is strictly biological. Two compounds, 9-(2-hydroxy-l-(hydroxymethyl)ethoxy)methyl] guanine (1b) and 9-(S)-(2,3-dihydroxypropyl)adenine (2), have received the most attention, but many others have been made. |
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