The Intracellular and Extracellular Fate of Oligodeoxyribonucleotides in Tissle Culture Systems |
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| Authors: | Marion Ceruzzi Kenneth Draper |
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| Institution: | Department of Antiviral Chemotherapy , Research Division Schering Corporation , 60 Orange Street, Bloomfield, N.J., 07003 |
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| Abstract: | Abstract In this study, we analyzed the intracellular and extracellular stability of an oligdeoxyribonucleotide (oligo 293) which exhibits antiviral activity against Herpes Simplex Virus Type 1 (HSV-1) in tissue culture. The uptake and stability of oligo 293 varied when cell type or internucleoside linkage was changed. |
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