Evaluation of Sulfur-Transfer Reagents for Large Scale Synthesis of Oligonucleotide Phosphorothioate Analogues |
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| Authors: | Zhaoda Zhang Alexandra Nichols Jimmy X. Tang Mazen Alsbeti Jin Yan Tang |
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| Affiliation: | Hybridon, Inc. , One Innovation Drive , Worcester, MA, 01605, USA |
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| Abstract: | Abstract Several sulfur-transfer reagents have been evaluated for large scale synthesis of oligonucleotide phosphorothioate analogues, in which 3-ethoxy-1, 2-dithiazoline-5-one (EDITH, 5) shows potential as an alternative to Beaucage reagent. |
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