Synthesis of Some New Nucleoside Analogues as Potential Antiviral Agents |
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| Authors: | M A Forestier A I Ayi R Condom B P Boyode J N Colin J Selway |
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| Institution: | 1. Université de NICE-SOPHIA ANTIPOLIS, Faculté des Sciences, Laboratoire de Chimie Bio-Organique , B.P. N[ddot] 71, F-06 108, NICE Cédex 2, FRANCE;2. The WELLCOME Foundation Ltd, the WELLCOME Research Laboratories , Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, ENGLAND |
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| Abstract: | Abstract A novel series of pyrimidine nucleoside analogues was synthesized. 2,3-Dideoxy-2,3-anhydro-β-D-lyxofuranose was opened by sodium azide to give the corresponding azido compound, which was reduced by lithium aluminium hydride to lead to 2,3-dideoxy-2,3-epimino-β-D-ribofuranose. Pyrimidine bases were glycosylated with this synthon to give potential antiviral molecules: 1-(2,3-dideoxy-2,3-epimino-β-D-ribofuranosyl)pyrimidines. |
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