A New Facile Synthesis and Antiviral Activity of Oxazofurin |
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| Authors: | P Franchetti L Messini L Cappellacci M Grifantini P Guarracino M E Marongiu |
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| Institution: | 1. Dipartimento di Scienze Chimiche , Università di Camerino , 62032, Camerino, Italy;2. Dipartimento di Biologia Sperimentale , Università di Cagliari , 09124, Cagliari, Italy |
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| Abstract: | Abstract A new, more facile synthesis of oxazofurin, a structural analogue of tiazofurin, selenazofurin and ribavirin, has been carried out by rhodium catalyzed reaction of ethyl α-formyl-diazoacetate with 2,3, 5-tri-O-benzoyl-β-D-ribofu-ranosyl cyanide. When evaluated against DNA and RNA viruses, HIV-1 inclu-ded, oxazofurin was found inactive. It was also ineffective in potentiating the anti-HIV activity of 2′, 3′-dideoxyadenosine. |
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